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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/001/02/0143-0149

    • Keywords

       

      Neurospora crassa ; copper toxicity; histidine biosynthesis; histidinol phosphate phosphatase

    • Abstract

       

      The inhibition of growth of a wild strain ofNeurospora crassa by Cu2+ is counteracted by histidine, histidine methyl ester, histidinol and Mn2+. In the presence of Cu2+, the total free amino acid content decreased by 30%. The decreased free amino acid pools of arginine, histidine and tyrosine were restored on the addition of Mn2+. Histidinol phosphate phosphatase showed a decrease in activity in the presence of Cu2+. This inhibition was reversed on the addition of excess Mn2+. The data suggest that copper toxicity in the mould is due to suppression of histidine biosynthesis.

    • Author Affiliations

       

      C Subramanyam1 G Venkateswerlu1

      1. Department of Biochemistry, Osmania University, Hyderabad - 500 007
    • Dates

       
  • Journal of Biosciences | News

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