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    • Distribution of acid and alkaline deoxyribonucleases in white and grey matter regions of growing and aging chick brain

      K Subba Rao K P Shrivastaw

      Volume 1 Issue 1 March 1979 pp 69-74

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/001/01/0069-0074

    • Keywords

       

      Acid deoxyribonucleases; alkaline deoxyribonucleases; aging; chick brain

    • Abstract

       

      The activities of acid and alkaline deoxyribonucleases in the white and grey matter areas of growing and old chick cerebrum were measured. Two marker enzymes for glial cells, butyrylcholinesterase and carbonic anhydrase were also measured in these regions. Higher specific activities of both butyrylcholinesterase and carbonic anhydrase were found in the white matter region at all the stages studied. Acid and alkaline deoxyribonuclease activities were observed in both white and grey matter. The decrease in the specific activity of acid deoxyribonuclease with advancement of age was more pronounced as compared to the alkaline deoxyribonuclease Marked reduction in total acid deoxyribonuclease activity in white matter, beyond the age of 130 days, was observed. On the other hand, total alkaline deoxyribonuclease activity in both white and grey matter continued to increase with age Further, the activity per mg of DNA also increased in white matter of the old brain. These results indirectly suggest a continued role for alkaline deoxyribonuclease in glial cells formed at a later age.

    • Author Affiliations

       

      K Subba Rao1 2 K P Shrivastaw1

      1. Biochemistry Division, Department of Chemistry, Banaras Hindu University, Varanasi - 221 005
      2. School of Life Sciences, University of Hyderabad, Hyderabad - 500 001

    • Dates

       
      Published
      March 1979
      Manuscript received
      15 November 1978
      Manuscript revised
      6 January 1979

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