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https://www.ias.ac.in/article/fulltext/boms/046/0035 -
Keywords
Nanomedicine ;therapeutic delivery ;drug transporters ;targeting ;mucoadhesion ;ocular diagnostics. -
Abstract
Drug delivery to the eye is challenging due to immediate drainage of eyedrops from the eye, low volume of the cul-de-sac (10–20 ${\mu}$l), the sensitivity of the corneal layer, physicochemical properties of a drug, biological barriers, need for repeated instillation, which finds difficulties for patients. Furthermore, it is difficult to carry drugs across the blood–retinal barrier, and across the cornea when administered systemically and topically, respectively, due to the limited absorption rate at a targeted site. Owing to the static and dynamic constraints associated with the eyes, the permeation of therapeutics to the back of the eye is limited. The use of drug delivery systems that can remain in contact with the ocular surface for a prolonged duration can greatly reduce the frequency of dosing, whereas drug delivery systems that cross ocular barriers may provide greater efficacy of administered drugs to inaccessible ocular tissues. In this review, we explored barrier properties of the ocular tissues, as well as the various drug transport mechanisms in the eye to design an effective strategy. This followed a discussion on the recent strategies to enhance the ocular distribution of therapeutics and have a future for translational nanomedicine.
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Graphical Abstract
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Author Affiliations
SAGAR R PARDESHI1 2 MAHESH P MORE3 ABHIJEET D KULKARNI4 CHANDRAKANTSING V PARDESHI5 PRITAM B PATIL6 ANKIT S PATIL1 PRABHANJAN S GIRAM7 HITENDRA S MAHAJAN5 PRASHANT K DESHMUKH3 PRADUM P IGE8 GOVIND K PATIL1 JITENDRA B NAIK1
- Department of Pharmaceutical Technology, University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon 425001, India
- Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, India
- Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, Malkapur 443101, India
- School of Pharmaceutical Sciences, Sandip University, Nashik 422213, India
- Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, India
- Department of Chemical Engineering, Shri S’ad Vidya Mandal Institute of Technology, Bharuch 392001, India
- Department of Pharmaceutics, Dr. D. Y. Patil Unitech Society’s, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri 411018, India
- Department of Pharmaceutics, Abasaheb Kakade College of B. Pharmacy, Ahmednagar 414503, India
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Dates
- Published
- 20 February 2023
- Manuscript received
- 24 June 2022
- Accepted
- 9 October 2022
- Final version published online
- 20 February 2023
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Bulletin of Materials Science
Volume 46, 2023
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