1. Home
    2. Journals
    3. Bulletin of Materials Science
    4. Volume 45
    5. All articles

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/045/0088

    • Keywords

       

      Antibacterial; antioxidant; coagulation; hemolysis; isoimperatorin; silver nanoparticles.

    • Abstract

       

      The isolated and pure biological compounds have been widely used in natural-based nanoparticles, entailing applications in medicine, cosmetics and nutrition. In this study, the toxic effects (in vitro) and biomedical applications of isoimperatorin-mediated green synthesized silver nanoparticles (Iso-AgNPs) were investigated. The in vitro antioxidant, antibacterial and cytotoxic potential were determined by using standard protocols. Besides, blood compatibility was determined by hemolysis and coagulation tests. Based on the obtained results, Iso-AgNPs showed enhanced antioxidant capacity in comparison with the crude isoimperatorin and were found effective against the pathogenic bacterial strains.Cell viability study reveals the safety of Iso-AgNPs on H1299 and MCF-7 cell lines, and no significant cytotoxicity was observed. The non-hemolytic effect of Iso-AgNPs on erythrocyte cells (RBCs) and the absence of coagulation indicate high blood compatibility of these nanoparticles, which make them unique in comparison to the other silver nanoparticles. Altogether, our finding confirms the biological advantages of Iso-AgNPs as a cyto- and blood-compatible antibacterial and antioxidant nano-metal.

    • Author Affiliations

       

      AZAM CHAHARDOLI1 FARSHAD QALEKHANI2 YALDA SHOKOOHINIA2 3 ALI FATTAHI2 4

      1. Department of Biology, Faculty of Sciences, Razi University, Kermanshah 6714414971, Iran
      2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran
      3. Ric Scalzo Institute for Botanical Research, Southwest College of Naturopathic Medicine, Tempe 85282, USA
      4. Medical Biology Research Center, Health Technologies Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran

    • Dates

       
      Published
      16 May 2022
      Manuscript received
      11 December 2021
      Accepted
      29 December 2021
      Final version published online
      16 May 2022

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2022-2023 Indian Academy of Sciences, Bengaluru.

Contact | Site index