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    • Keywords


      Polycaprolactone; gelatin; casein; electrospinning; cartilage tissue engineering.

    • Abstract


      Cartilage regeneration/reconstruct is a noticeable challenge in cartilage tissue engineering. In this study, through electrospinning technique, poly(caprolactone) (PCL), gelatin (Gel) and casein (Cas) were used to fabricate electrospun scaffold for cartilage tissue engineering applications. The physicochemical properties of fabricated scaffolds were assessed by scanning electron microscopy (SEM), water contact angle (WCA), mechanical assessment, water uptake measurement and in-vitro degradation assay. The cell/scaffold interactions were assessed through MTT assay and SEM observation. The obtained results showed the uniform and bead-free PCL/Gel/Cas fibres produced with a mean diameter of about 259.27 ± 56.33 nm, and 15.98 ± 2.14 lm pore size. The tensile assessment revealed that PCL/Gel fibres with 2 wt% Cas reached 9.8 ± 1.6 MPa. The MTT assay also showed that PCL/Gel fibres with 2 wt% Cas had proper cell viability and proliferation comparable with PCL/Gel scaffold. It can be concluded that the PCL/Gel/Cas nanofibrous scaffold can be a desirable candidate for cartilage tissue engineering.

    • Author Affiliations



      1. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan 88137-33395, Iran
      2. Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 88137-33395, Iran
      3. Faculty of New Sciences and Technologies, Semnan University, Semnan 83138-53641, Iran
      4. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Shahrekord 14619-88631, Iran
    • Dates

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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