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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/045/0076

    • Keywords

       

      Polycaprolactone; gelatin; casein; electrospinning; cartilage tissue engineering.

    • Abstract

       

      Cartilage regeneration/reconstruct is a noticeable challenge in cartilage tissue engineering. In this study, through electrospinning technique, poly(caprolactone) (PCL), gelatin (Gel) and casein (Cas) were used to fabricate electrospun scaffold for cartilage tissue engineering applications. The physicochemical properties of fabricated scaffolds were assessed by scanning electron microscopy (SEM), water contact angle (WCA), mechanical assessment, water uptake measurement and in-vitro degradation assay. The cell/scaffold interactions were assessed through MTT assay and SEM observation. The obtained results showed the uniform and bead-free PCL/Gel/Cas fibres produced with a mean diameter of about 259.27 ± 56.33 nm, and 15.98 ± 2.14 lm pore size. The tensile assessment revealed that PCL/Gel fibres with 2 wt% Cas reached 9.8 ± 1.6 MPa. The MTT assay also showed that PCL/Gel fibres with 2 wt% Cas had proper cell viability and proliferation comparable with PCL/Gel scaffold. It can be concluded that the PCL/Gel/Cas nanofibrous scaffold can be a desirable candidate for cartilage tissue engineering.

    • Author Affiliations

       

      MEHDI MOVAHEDI1 2 AMIN ORASH MAHMOUD SALEHI3 FATEMEH POODINEH HAJIPOUR4 SINA ETEMAD4

      1. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan 88137-33395, Iran
      2. Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 88137-33395, Iran
      3. Faculty of New Sciences and Technologies, Semnan University, Semnan 83138-53641, Iran
      4. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Shahrekord 14619-88631, Iran

    • Dates

       
      Published
      25 April 2022
      Manuscript received
      23 June 2021
      Accepted
      14 December 2021
      Final version published online
      25 April 2022

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