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      https://www.ias.ac.in/article/fulltext/boms/044/0191

    • Keywords

       

      Silver nano-cubes; nano-spheres; antimicrobial; anti-biofilm; synergistic.

    • Abstract

       

      Silver nanomaterials (AgNMs) ubiquitously known for their biological applications are studied here in terms of their shape-dependent antibacterial and anti-biofilm effect. Chemically synthesized nano-cubes (AgNCs) with size range around 150–200 nm were compared for their biological activity with commercial nano-sphere (AgNS) of comparable size (${\sim}$160 nm). The antibacterial activity against both Escherichia coli and Staphylococcus aureus showed higher activity for nano-cubes compared with nano-spheres.The synergistic role of AgNMs with antibiotic ampicillin was also found promising. A four times enhancement and an increase of nearly 25% of antibiotic activity at 0.0625 mg ml$^{–1}$ concentration was found with 0.05 mg ml$^{–1}$ of AgNCs in agar and broth media, respectively. Anti-biofilm effect towards E. coli and S. aureus was also evaluated. AgNCs showed equal importance in biofilm disruption with 20% inhibition activity, which was yet again found better in-comparison with AgNSs. The study shows that AgNCs with distinct faces and edges could show efficient anti-bacterial effect and so such intelligently designed material could pave path for imminent medical challenges.

    • Author Affiliations

       

      NEHA AGRAWAL1 PRIYANKA MISHRA2 RAHUL RANJAN1 PUNAM AWASTHI3 ALOK SRIVASTAVA3 DEEPTI PRASAD1 EKTA KOHLI1

      1. Department of Neurobiology, DIPAS, DRDO, Delhi 110054, India
      2. Department of Immunomodulation, DIPAS, DRDO, Delhi 110054, India
      3. Directorate of Nanotechnology, DMSRDE, DRDO, Kanpur 208013, India
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    • Supplementary Material

       
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