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      https://www.ias.ac.in/article/fulltext/boms/044/0132

    • Keywords

       

      G. lucidum; biofabrication; gold nanoparticles; cytotoxicity.

    • Abstract

       

      Ganoderma lucidum (G. lucidum) is a medicinal mushroom, which is rich in flavonoids as well as polyphenols and contains triterpenes, ganoderic acid. Thus, this research examined the biosynthesis of gold nanoparticles(GNPs) using G. lucidum fruit body and their cytotoxicity, cell morphology and apoptosis detection against HT-29 colon cancer cell line. The study results revealed the occurrence of GNPs, as evidenced by ultraviolet–visible spectroscopy(UV–vis spectroscopy; 520 nm). The X-ray diffraction results show that the synthesized Au-NPs are crystalline. According to field-emission scanning electron microscope, transmission electron microscopy and atomic force microscope,the synthesized GNPS exhibited shapes such as spherical, oval and irregular in shape and the size ranges in between 1 and 100 nm. G. lucidum biofabricated GNPs showed inhibited HT-29 colon cancer cell line with an efficacy IC$_{50}$ of 84.58 ${\mu}$g ml$^{–1}$. The results indicated that the apoptotic effects were increased on cells based on the dose-dependent concentration of GNPs.

    • Author Affiliations

       

      D ELUMALAI1 T Y SUMAN2 3 M HEMAVATHI4 C SWETHA1 R KAVITHA5 C ARULVASU5 P K KALEENA6

      1. PG Department of Zoology, Pachaiyappas College for Men, Kanchipuram 631501, India
      2. School of Civil, Environmental and Chemical Engineering, Changwon National University, Changwon 51140, Republic of Korea
      3. Ecotoxicology Division, Centre for Ocean Research (DST-FIST Sponsored Centre), Sathyabama Institute of Science and Technology, Chennai 600119, India
      4. Department of Zoology, Arignar Anna Govt. Arts & Science College for Women, Vellore 632513, India
      5. Department of Zoology, Guindy Campus, University of Madras, Chennai 600 025, India
      6. Department of Zoology, Presidency College, Chennai 600005, India
    • Dates

       
  • Bulletin of Materials Science | News

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