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      https://www.ias.ac.in/article/fulltext/boms/044/0087

    • Keywords

       

      Cisplatin; anticancer; polyamindoamine dendrimer (PAMAM); polyacrylic; cytotoxicity.

    • Abstract

       

      Platinum complexes have paid much attention to develop new drugs for cancer therapy due to its inhibitory activity against cancerous cell growth. In the study, the strategically programming cationic PAMAM G4.0 with carboxylate motifs was introduced as a delivery platform for cisplatin. Partial amino groups on the surface of PAMAM G4.0 had coupled with active carboxylate groups on polyacrylic acid (PAA) in order to reduce the remaining problem of cationic dendrimer and improve delivery effectiveness of aquated cisplatin. Our results show that the full cationic PAMAM G4.0 was toxic against both breast cancer (MCF7) and human dermal fibroblast (HuDF) cell lines at 100 ppm concentration. In the contract, the PAA-conjugated PAMAM G4.0 significantly improved their cytocompatibility of the cationic dendrimer. In addition, the modified PAMAM dendrimers G4.0 showed high affinity with the aquated cisplatindue to the presence of abundant carboxylic groups. Notably, the aquated cisplatin-complexed PAA-G4.0 showed 2.94- folded reduction in the toxicity against NCI H460 in comparison to free cisplatin drugs. Hence, the G4.0-PAA/aquated cisplatin nano-complex may become a promising versatile strategy for improving antitumour efficacy and reducing the side effects of platinum-based drugs.

    • Author Affiliations

       

      NGOC HOA NGUYEN1 2 LE HANG DANG2 3 PHUONG DOAN3 CHAN KHON HUYNH4 CUU KHOA NGUYEN2 3 BICH TRAM NGUYEN5 NGOC TUNG NGUYEN6 NGOC QUYEN TRAN2 3 4

      1. German Vietnamese Technology Center, HCMC University of Food Industry, Ho Chi Minh City 700000, Vietnam
      2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam
      3. Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam
      4. School of Biomedical Engineering, International University, National Universities in HCMC, HCMC 700000, Vietnam
      5. Department of Natural Science, Thu Dau Mot University, Thu Dau Mot, Binh Duong Province, Vietnam
      6. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi, Vietnam
    • Dates

       
  • Bulletin of Materials Science | News

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