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https://www.ias.ac.in/article/fulltext/boms/043/0248

Montmorillonite; tetracycline hydrochloride; antibacterial activity; in-vitro drug release.

Nanoclay-based drug delivery vehicle has acquired immense recognition owing to its unique physico-chemical properties. In this study, tetracycline hydrochloride (TCH) drug was intercalated into the interlayer gallery of montmorillonite (Mt) clay by a cation exchange process. The intercalated nanocomposites were characterized by Fourier transform infraredspectroscopy, X-ray diffraction, energy dispersive X-ray and thermogravimetric study. It was evident from the characterization that TCH drug was successfully intercalated into the interlayer gallery of Mt clay. These clay-based formulations exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria on analyses via zone inhibitionmethods. An in-vitro drug release study was performed in phosphate buffer at physiological temperature and interestingly it exhibited sustained and controlled release of TCH from the nanocomposites, after an initial burst-out effect. Overall, this study showed that these nanocomposite materials have immense potential for use in controlled drug delivery strategies for antibacterial treatment.

KOUSHIK DUTTA¹ KASTURI SAHA¹ PRIYABRATA SARKAR¹ DIPANKAR CHATTOPADHYAY¹

1. Department of Polymer Science and Technology, University of Calcutta, Kolkata 700009, India

Published

28 August 2020

Manuscript received

24 November 2019

Accepted

19 March 2020

Final version published online

28 August 2020