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      https://www.ias.ac.in/article/fulltext/boms/043/0248

    • Keywords

       

      Montmorillonite; tetracycline hydrochloride; antibacterial activity; in-vitro drug release.

    • Abstract

       

      Nanoclay-based drug delivery vehicle has acquired immense recognition owing to its unique physico-chemical properties. In this study, tetracycline hydrochloride (TCH) drug was intercalated into the interlayer gallery of montmorillonite (Mt) clay by a cation exchange process. The intercalated nanocomposites were characterized by Fourier transform infraredspectroscopy, X-ray diffraction, energy dispersive X-ray and thermogravimetric study. It was evident from the characterization that TCH drug was successfully intercalated into the interlayer gallery of Mt clay. These clay-based formulations exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria on analyses via zone inhibitionmethods. An in-vitro drug release study was performed in phosphate buffer at physiological temperature and interestingly it exhibited sustained and controlled release of TCH from the nanocomposites, after an initial burst-out effect. Overall, this study showed that these nanocomposite materials have immense potential for use in controlled drug delivery strategies for antibacterial treatment.

    • Author Affiliations

       

      KOUSHIK DUTTA1 KASTURI SAHA1 PRIYABRATA SARKAR1 DIPANKAR CHATTOPADHYAY1

      1. Department of Polymer Science and Technology, University of Calcutta, Kolkata 700009, India
    • Dates

       
  • Bulletin of Materials Science | News

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