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      https://www.ias.ac.in/article/fulltext/boms/043/0232

    • Keywords

       

      Chitosan; targeted drug delivery; passive drug delivery; PEGylation; ex vivo study; carbohydrate recognition domains.

    • Abstract

       

      Till date, several studies have reported magnetic drug targeting as well as passive drug delivery. In this study, the passive characteristic of PEGylated carriers with a neutral surface charge rather than chitosan (CS)-based nanoparticles (NPs) with a positive charge was proved using molecular docking. The complete and without flaw stealth CS-coated magnetic NPs (mNPs) loaded with an anticancer drug for intravenous drug delivery were prepared using a modified ionic crosslinking method. The physicochemical properties of the prepared magnetic-CS NPs were characterized in detail. The transmission electron micrographs of NPs showed an uniform particle morphology with an average diameter of smaller than 10 nm. The average IC50 values of the drug in PEGylated NPs for MCF-7 and PC-12 cells were 44 and 72 lM, respectively. The fabricated stealth NPs can increase the cytotoxicity and cell permeability of formulation that may release the entire drug in targeted shape to objective tissues that were firstly proved by molecular docking. This strategy showed a reduction in up taking of mNPs by the reticuloendothelial system, which indeed increases the concentration of therapeutic agent(s) in the target site.

    • Author Affiliations

       

      ABBAS HEMATI AZANDARYANI1 2 SOHEILA KASHANIAN1 2 YADOLLAH BAHRAMI3 4 5 MOHSEN SHAHLAEI2 KATAYOUN DERAKHSHANDEH6 SAJAD MORADI2

      1. Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran
      2. Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
      3. Department of Medical Biotechnology, School of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia
      4. Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran
      5. Molecular Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran
      6. Department of Pharmaceutics, Faculty of Pharmacy, Hamedan University of Medical Sciences, Hamedan 6517838678, Iran
    • Dates

       
  • Bulletin of Materials Science | News

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