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      https://www.ias.ac.in/article/fulltext/boms/043/0217

    • Keywords

       

      Ibuprofen; hyperbranched polyester; morphological properties; antimicrobial activity.

    • Abstract

       

      Herein we report the synthesis of ibuprofen-based hyperbranched polyester ranging from morphological, thermal and fluorescent behaviour. The proposed synthesis of ibuprofen-based hyperbranched polyester was achieved by asimple acid chloride approach. The formation of aromatic ester linkage in the product was confirmed using Fourier transform infrared and nuclear magnetic resonance spectroscopy. The morphology of ibuprofen-based hyperbranchedpolyester was investigated by using the X-ray diffraction, scanning electron microscopy and differential scanning calorimetry (DSC) analyses. The glass transition temperature ($\sim$78$^{\circ}$C) and double melting peaks of ibuprofen-based hyperbranched polyester were observed using DSC. The liquid chromatography-mass spectrometry analysis confirmed the chemical structure and the molecular weight of the ibuprofen-based hyperbranched polyester. The presence of broad absorption peak at 301 nm in UV region indicated the fluorescent property of ibuprofen-based hyperbranched polyester.The antimicrobial tests of ibuprofen-based hyperbranched polyester were carried against Gram-negative organisms such as Escherichia coli MCIM 2065 and Salmonella paratyphi MCIM 2501, Gram-positive organisms such as Bacillus subtilis NCIM 2063 and Staphylococcus aureus NCIM 2079 and fungi such as Aspergillus niger MTCC 1344 and Candida albicans MTCC 3100. The result of agar disc diffusion method showed that the polymer had higher antimicrobial potential towards fungi than bacteria.

    • Author Affiliations

       

      SWAMINATHAN PRABU1 A SULTAN NASAR2 CHICKIYAN SIVAKUMAR3

      1. Department of Chemistry, Sri Krishna College of Technology, Coimbatore 641 042, India
      2. Department of Polymer Science, University of Madras, Chennai 600 025, India
      3. Department of Chemistry, JCT College of Engineering and Technology, Coimbatore 641 105, India
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