• Sacrificial sulphonated polystyrene template-assisted synthesis of mesoporous hollow core-shell silica nanoparticles for drug-delivery application

• # Fulltext

https://www.ias.ac.in/article/fulltext/boms/043/0213

• # Keywords

Hollow core-shell silica nanoparticles; polystyrene; drug delivery.

• # Abstract

Spherical mesoporous hollow core-shell silica nanoparticles (HCSNs) of size $200 \pm 50$ nm with tunable thickness from 20 to 60 nm are synthesized using a sacrificial sulphonated polystyrene (PS, particle size 160 nm) template. A facile method is adopted for the sulphonation of PS using sulphuric acid, which enhanced the negative charge on the surface of PS as confirmed by zeta potential analysis and Fourier transform infrared radiation analysis. The thickness of the silica shell is tuned by altering the concentration of the silica precursor and is found to increase due to the use of the sulphonated PS template. N$_2$ adsorption/desorption studies reported the variation of specificsurface area of HCSNs from 644.1 to 197.8 m$^ 2$ g$^{-1}$ and average pore size from 1.55 to 3.4 nm. The drug release behaviour of HCSNs with different shell thicknesses is investigated using doxorubicin as the model drug. A delay inthe drug release for $\sim$300 min is successfully achieved by employing HCSNs with enhanced thickness of 60 nm. Application of HCSNs in targeted drug delivery was further supported by the in-vitro cytotoxicity studies carried out on lung adenocarcinoma cells.

• # Author Affiliations

1. National Institute of Technology Karnataka, Surathkal, Mangalore 575025, India

• # Bulletin of Materials Science

Volume 43, 2020
All articles
Continuous Article Publishing mode

• # Dr Shanti Swarup Bhatnagar for Science and Technology

Posted on October 12, 2020

Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020