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      https://www.ias.ac.in/article/fulltext/boms/043/0172

    • Keywords

       

      Cationic surfactant; worm-like micelles; hydrogels; viscoelasticity; xerogels; supramolecular interactions.

    • Abstract

       

      Design of amphiphiles to develop robust self-assembled soft nanomaterials, such as micelles and hydrogels is an interesting subject. A series of cationic amphiphilic compounds were synthesized comprising 1-ethoxy (3-pentadecyl)benzene as the hydrophobic tail. The second carbon of ethoxy was linked to quaternary head groups (trimethyl ammonium bromide (PEA), triethyl ammonium bromide (PETE), pyridinium bromide (PEPy), N-methyl morpholino bromide (PENM), N-methyl piperidine bromide (PENP)). Inclusion of benzene ring leads to a significant decrease in critical micellar concentration (CMC) as compared to other cationic surfactants, such as cetyl trimethyl ammonium bromide (CTAB). Interestingly, at higher concentration, these cationic amphiphiles were forming soft hydrogels with critical gelation concentration (CGC) from 3 to 10% (w/v). The small-angle X-ray scattering (SAXS) analysis of xerogel revealed the formation of self-assembled lamellar patterns of molecules. Further, the morphology of xerogels were also seen under a scanning electron microscope (SEM) which correlates with SAXS data. The SAXS and SEM data confirms the formation of worm-like micellar structures and entangle themselves to form a hydrogel. The cytotoxicity assay was done on HDFA, HeLa and HEK cell lines, haemolysis assay showed better haemocompatibility than CTAB. The synthesized surfactants exhibited up to 3-fold higher solubilization capability against hydrophobic molecules than CTAB.

    • Author Affiliations

       

      OMPRAKASH SUNNAPU1 2 PRIUSHA RAVIPATI1 PREETHEM SRINATH1 SANJEEB KALITA1 PRATIKSHA P BHAT1 S R HARSHITHA1 KARUPPANNAN SEKAR2 PRAVEEN KUMAR VEMULA1 MANOHAR MAHATO1

      1. Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bengaluru 560065, India
      2. Department of Chemistry, Anna University, University College of Engineering, Dindigul 624622, India
    • Dates

       
  • Bulletin of Materials Science | News

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