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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/043/0172

    • Keywords

       

      Cationic surfactant; worm-like micelles; hydrogels; viscoelasticity; xerogels; supramolecular interactions.

    • Abstract

       

      Design of amphiphiles to develop robust self-assembled soft nanomaterials, such as micelles and hydrogels is an interesting subject. A series of cationic amphiphilic compounds were synthesized comprising 1-ethoxy (3-pentadecyl)benzene as the hydrophobic tail. The second carbon of ethoxy was linked to quaternary head groups (trimethyl ammonium bromide (PEA), triethyl ammonium bromide (PETE), pyridinium bromide (PEPy), N-methyl morpholino bromide (PENM), N-methyl piperidine bromide (PENP)). Inclusion of benzene ring leads to a significant decrease in critical micellar concentration (CMC) as compared to other cationic surfactants, such as cetyl trimethyl ammonium bromide (CTAB). Interestingly, at higher concentration, these cationic amphiphiles were forming soft hydrogels with critical gelation concentration (CGC) from 3 to 10% (w/v). The small-angle X-ray scattering (SAXS) analysis of xerogel revealed the formation of self-assembled lamellar patterns of molecules. Further, the morphology of xerogels were also seen under a scanning electron microscope (SEM) which correlates with SAXS data. The SAXS and SEM data confirms the formation of worm-like micellar structures and entangle themselves to form a hydrogel. The cytotoxicity assay was done on HDFA, HeLa and HEK cell lines, haemolysis assay showed better haemocompatibility than CTAB. The synthesized surfactants exhibited up to 3-fold higher solubilization capability against hydrophobic molecules than CTAB.

    • Author Affiliations

       

      OMPRAKASH SUNNAPU1 2 PRIUSHA RAVIPATI1 PREETHEM SRINATH1 SANJEEB KALITA1 PRATIKSHA P BHAT1 S R HARSHITHA1 KARUPPANNAN SEKAR2 PRAVEEN KUMAR VEMULA1 MANOHAR MAHATO1

      1. Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bengaluru 560065, India
      2. Department of Chemistry, Anna University, University College of Engineering, Dindigul 624622, India

    • Dates

       
      Published
      29 July 2020
      Manuscript received
      19 August 2019
      Accepted
      20 December 2019
      Final version published online
      29 July 2020

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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