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      https://www.ias.ac.in/article/fulltext/boms/043/0092

    • Keywords

       

      Anabaena flos-aquae; anticancer drugs; breast cancer; silver nanoparticles.

    • Abstract

       

      Silver nanoparticles (AgNPs) are one of the new cancer treatment tools due to their unique properties that enhance potential therapeutic efficacy. In this study, we describe the extracellular biosynthesis and anticancer activity ofAgNPs using the Anabaena flos-aquae biomass extract as reducing agent. The formation of dark-brown AgNO$_3$/extract solution confirmed the reduction of silver ions into AgNPs. In addition, the ultraviolet–visible spectroscopy showed the surface plasmon peak at 425 nm as characteristic peak for AgNPs. Transmission electron microscopy and scanning electron microscopy showed highly stable and mostly spherical AgNPs with average size of 5–25 nm. Fourier transform infrared spectral analysis confirmed the presence of biomolecules in the extract involved in the reduction and stabilization of AgNPs. In vitro, study of anticancer and cytotoxic effect of AgNPs and extract against T47D cell lines by MTT assay and flowcytometry confirmed the anti-proliferation potential of AgNPs against breast cancer cells. In conclusion, our results revealed that Anabaena can be used as a good organism for biologically synthesis of AgNPs and confirmed the potent therapeutic value of these nanoparticles as anticancer drugs.

    • Author Affiliations

       

      Z EBRAHIMZADEH1 A SALEHZADEH1 A S NAEEMI2 A JALALI3

      1. Department of Biology, Rasht Branch, Islamic Azad University, Rasht 4147654919, Iran
      2. Department of Biology, Faculty of Sciences, University of Guilan, Rasht 41996-13776, Iran
      3. Department of Biology, Faculty of Sciences, Arak University, Arak 38156-8-8349, Iran
    • Dates

       
  • Bulletin of Materials Science | News

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