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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/043/0070

    • Keywords

       

      Peptide amphiphile; hydrogel; anti-parallel $\beta$-sheet; supramolecular; thixotropic.

    • Abstract

       

      Peptide-amphiphile (PA)-based supramolecular thixotropic hydrogels are useful in medical sciences due to multiple advantageous features along with its biocompatibility and biodegradability. In this work, we have developed aself-assembled peptide-based hydrogel from a $\beta$-sheet forming short PA. Hydrogelation of the PA is controlled by pH and consequent changes in secondary structures attained by the PA. Under acidic conditions, the PA remains in random coil conformation. While increasing the pH to 9, a rapid transformation to anti-parallel β-sheet leads to a strong hydrogel. Interestingly, the disulphide-linked dimer of the PA failed to attain such aggregation pattern. The pH-induced sol–gel–sol transition can be achieved for several cycles without any change in aggregation pattern. The hydrogel was also found to show thixotropic rheological behaviour and thus, it can be utilized as an injectable hydrogel for biomedical applications.

    • Author Affiliations

       

      PAYEL DOWARI1 BAPAN PRAMANIK1 DEBAPRATIM DAS1

      1. Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Kamrup 781039, India

    • Dates

       
      Published
      12 February 2020
      Manuscript received
      8 July 2019
      Accepted
      26 September 2019
      Final version published online
      12 February 2020

    • Supplementary Material

       

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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