The present article reports on the synthesis of mesoporous alumina and its modification through $\beta$-cyclodextrin (BCD) incorporation for loading and release studies of amoxicillin. The drug loading in the mesoporous matrices was found to be activated upon providing molecular assistance by amino acids, L-methionine, L-proline and L-phenylalanine. The effect of molecular assistance has been attributed to intermolecular interactions between the drug and the individual amino acids which have been further confirmed by different spectroscopic studies. The drug-loaded material with BCD modification wasfound to exhibit a sustained release mechanism in physiological pH and is suggested as a proposed material for hip joint prosthesis.
Volume 44, 2021
Continuous Article Publishing mode
Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020
Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
Physical Sciences 2020
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