• Pristine and modified-mesoporous alumina: molecular assistance-based drug loading and sustained release activity

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    • Keywords

       

      Mesoporous alumina; $\beta$-cyclodextrin; molecular assistance; sustained release; amoxicillin.

    • Abstract

       

      The present article reports on the synthesis of mesoporous alumina and its modification through $\beta$-cyclodextrin (BCD) incorporation for loading and release studies of amoxicillin. The drug loading in the mesoporous matrices was found to be activated upon providing molecular assistance by amino acids, L-methionine, L-proline and L-phenylalanine. The effect of molecular assistance has been attributed to intermolecular interactions between the drug and the individual amino acids which have been further confirmed by different spectroscopic studies. The drug-loaded material with BCD modification wasfound to exhibit a sustained release mechanism in physiological pH and is suggested as a proposed material for hip joint prosthesis.

    • Author Affiliations

       

      PRITAM SINGH1 P K MAITI2 KAMALIKA SEN1

      1. Department of Chemistry, University of Calcutta, Kolkata 700009, India
      2. Department of Chemical Technology, University of Calcutta, Kolkata 700009, India
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