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    • Keywords

       

      Physalis alkekengi-L; chitosan nanoparticles; antioxidant activity; stability of extract.

    • Abstract

       

      Physalis alkekengi-L is a medicinal herb with a high antioxidant capacity. It is used to treat various diseases. In this study, encapsulation of the hydro-alcoholic extract of P. alkekengi-L into chitosan nanoparticles (CNPs) was optimized by using response surface methodology, and its antioxidant capacity and anticancer activity were investigated. The results ofthe antioxidant capacity evaluation showed that the antioxidant activity of the chitosan nanoparticles containing extract did not significantly decrease by increasing the time of storage (over a 12 day period) as compared to that of un-encapsulated extracts. In conclusion, CNPs can be used to encapsulate and improve the stability of P. alkekengi-L extract and its antioxidantproperties.

    • Author Affiliations

       

      REZA MAHMOUDI1 MARYAM TAJALI ARDAKANI1 BEHNAM HAJIPOUR VERDOM2 ABOUZAR BAGHERI3 HOSSEIN MOHAMMAD-BEIGI4 FARHANG ALIAKBARI5 6 ZEINAB SALEHPOUR7 MOHSEN ALIPOUR8 SAJAD AFROUZ1 HASSAN BARDANIA1

      1. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj 7591994799, Iran
      2. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-111, Iran
      3. Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48471–91971, Iran
      4. Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark
      5. Bioprocess Engineering Department, Institute of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran 1497716316, Iran
      6. Department and Center for Biotechnology Research, School of Medicine, Semnan 35198-99951, Iran
      7. Medicinal Plant Research Center, Yasuj University of Medical Sciences, Yasuj 7591994799, Iran
      8. Department of Advanced Medical Sciences and Technologies, School of Medicine, Jahrom University of Medical Sciences, Jahrom 7414846199, Iran
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