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    • Keywords


      Bioactive glass; $\alpha$-calcium sulphate hemihydrate; composite; bioactivity; cytocompatibility.

    • Abstract


      To combine the self-setting property of $\alpha$-calcium sulphate hemihydrate ($\alpha$-CSH) with the bioactive property of bioactive glass (BG), BG was added into $\alpha$-CSH to prepare $\alpha$-CSH/BG composites. The in vitro bioactivity and cytocompatibility of the $\alpha$-CSH/BG composites were assessed by soaking the composites in simulated body fluid (SBF) andco-culturing with the osteoblasts, respectively. Formation of a bone-like apatite layer on the composite surface was studied by X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), scanning electron microscopy (SEM) andenergy-dispersive spectroscopy (EDS). Variations in ionic concentration and pH of the SBF solution were detected. The incorporation of BG into $\alpha$-CSH, effectively compensated for the pH decrease caused by the dissolution of $\alpha$-CSH and the ion exchange.Osteoblast-like cells (MG63) were cultured on the samples, and theMTTresults confirmed that the compositescontaining BG were more favourable for the proliferation of these cells. Hence, $\alpha$-CSH/BG composites might have great potential for the use as a bone regeneration material.

    • Author Affiliations



      1. School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, People’s Republic of China
      2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China
    • Dates

  • Bulletin of Materials Science | News

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      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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