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      https://www.ias.ac.in/article/fulltext/boms/041/01/0018

    • Keywords

       

      Advanced textiles; chronic wound healing; electrospinning; sodium bicarbonate; pantothenic acid.

    • Abstract

       

      In the present work, an electrospun nanofibrous textile composed of polyurethane (PU), sodium bicarbonate(NaHCO3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problemand in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number ofmorbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidicenvironment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism.Hence, various types of advanced textile-based dressings are developed to address the clinical complications associated withchronic wound management. The prepared electrospun scaffolds were characterized to study their physicochemical andhaemocompatible properties. The scanning electron microscopy micrographs depicted continuous, smooth-interconnectednanofibrous morphology of PU–NaHCO$_3$–PA scaffolds. The Fourier transform infrared spectroscopy spectra indicatedthe addition of NaHCO$_3$ and PA-based hydrophilic chemical groups, which significantly enhanced the wettability of thecomposites. Further, the PU–NaHCO$_3$–PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4 $\pm$ 4.8%, which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly haemocompatible surface by delaying coagulation of blood through contact activationpathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibilityand the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.

    • Author Affiliations

       

      ISABEL HERRMANN1 2 EKO SUPRIYANTO1 SARAVANA KUMAR JAGANATHAN3 4 5 A MANIKANDAN6

      1. Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai 81300, Malaysia
      2. Ilmenau Institute of Biomedical Engineering and Computer Science, Technical University of Ilmenau, 98693 Ilmenau, Germany
      3. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
      4. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
      5. IJNUTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai 81300, Malaysia
      6. Department of Chemistry, Bharath Institute of Higher Education and Research, Bharath University, Chennai 600073, India
    • Dates

       
  • Bulletin of Materials Science | News

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