In recent decades, the use of microparticle-mediated drug delivery is widely applied in the field of biomedicalapplication. Here, we report the new dressing material with ciprofloxacin-loaded chitosan microparticle (CMP) impregnatedin chitosan (CH) and poly(vinyl alcohol) (PVA) scaffold for effective delivery of drug in a sustained manner to thewound site.Moreover, the peculiar physiochemical and structural properties of the CH–CMP scaffold has proved better tensile strengthand excellent swelling to achieve 82% of drug release. In vitro biocompatibility was done for both scaffold using NIH 3T3 fibroblasts and human keratinocytes (HaCaT) cell lines. In vitro fluorescent activity showed distinct biocompatibility withgood cell adhesion and proliferation. However, the CH–CMP scaffold showed best result to act as promising biomaterial in effective drug delivery in tissue engineering.
Volume 42 | Issue 6
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