• Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      Biocompatibility; tissue engineering; wound dressing; microparticle; scaffold.

    • Abstract


      In recent decades, the use of microparticle-mediated drug delivery is widely applied in the field of biomedicalapplication. Here, we report the new dressing material with ciprofloxacin-loaded chitosan microparticle (CMP) impregnatedin chitosan (CH) and poly(vinyl alcohol) (PVA) scaffold for effective delivery of drug in a sustained manner to thewound site.Moreover, the peculiar physiochemical and structural properties of the CH–CMP scaffold has proved better tensile strengthand excellent swelling to achieve 82% of drug release. In vitro biocompatibility was done for both scaffold using NIH 3T3 fibroblasts and human keratinocytes (HaCaT) cell lines. In vitro fluorescent activity showed distinct biocompatibility withgood cell adhesion and proliferation. However, the CH–CMP scaffold showed best result to act as promising biomaterial in effective drug delivery in tissue engineering.

    • Author Affiliations



      1. Bioproducts Lab, CSIR-Central Leather Research Institute, Chennai 600020, India
    • Dates

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.