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    • Comparative study of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn and their anticancer efficacy

      D MUKUNDAN R MOHANKUMAR R VASANTHAKUMARI

      Volume 40 Issue 2 April 2017 pp 335-344

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/040/02/0335-0344

    • Keywords

       

      Bauhinia tomentosa Linn; silver nanoparticles; gold nanoparticles; A-549; HEp-2; MCF-7.

    • Abstract

       

      Nanotechnology is an emerging field in science and technology, which can be applied to synthesize new materials at the nanoscale level. The present investigation aimed at comparing the synthesis, characterization andin vitro anticancer efficacy of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn. Silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) were synthesized using aqueous extractof leaves with solution of silver nitrate (AgNO$_3$, 1 mM) and chloroauric acid (HAuCl$_4$·3H$_2$O, 1 mM), respectively. The synthesized nanoparticles were characterized using UV–visible spectrophotometry, Fourier transform infraredspectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive analysis of X-rays, X-ray diffraction, thermogravimetric analysis and cyclic voltammetry, which confirmed the reduction of Ag$^+$ ions to Ag$^0$ and Au$^{3+}$ ions to Au$^{0}$. The in vitro anticancer efficacy of AgNPs, AuNPs and aqueous extract of leaves confirmed by MTT assay exhibited IC50 concentrations of 28.125, 46.875 and 50 $\mu$gml$^{−1}$ for lung A-549 cells, 103.125, 34.375 and 53.125 $\mu$gml$^{−1}$ for HEp-2 cells and 62.5, 23.4 and 13.26 $\mu$gml$^{−1}$ for MCF-7 cells, respectively. The concentrations indicate that both silver and gold nanoparticles as well as aqueous extract of leaves exhibited high anticancer efficacy.

    • Author Affiliations

       

      D MUKUNDAN1 R MOHANKUMAR2 R VASANTHAKUMARI1

      1. Polymer Nano Technology Centre, B S A Crescent University, Chennai 600 048, India
      2. Interdisciplinary Institute of Indian System of Medicine, SRM University, Kattankulathur, Chennai 603203, India

    • Dates

       
      Published
      15 April 2017
      Manuscript received
      20 April 2016
      Accepted
      2 July 2016

  • Bulletin of Materials Science | News

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