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      https://www.ias.ac.in/article/fulltext/boms/040/02/0263-0270

    • Keywords

       

      Silica nanoparticles; glyburide; sustained release; sol–gel method.

    • Abstract

       

      The aim of this study was to develop sustained-release glyburide-loaded silica nanoparticles. Silica nanoparticles were synthesized by the sol–gel method using tetra-ethyl ortho-silane as a precursor. Glyburide was successfully entrapped in synthesized silica nanoparticles. To identify the effect of independent variables (concentration of silica and concentration of glyburide) on encapsulation efficiency and drug release (dependent variables), 3$^2$ (three level-two factors) response surface methodology was employed. Silica nanoparticles and glyburide-loaded silica nanoparticles were characterized by scanning electron microscopy, BET surface area, X-ray diffraction andFourier transformed infrared spectroscopy. The optimum values of encapsulation efficiency and drug release were 70.21 and 87.8% over 24 h, respectively; these values agree well with predicted values obtained by response surfacemethodology. Glyburide-loaded silica nanoparticles were successfully prepared without any incompatibility and seem to be promising for sustained-release drug delivery application and better patient compliance.

    • Author Affiliations

       

      JAYESH S PATIL1 PRITAM B PATIL1 PRAVIN SONAWANE1 JITENDRA B NAIK1

      1. Department of Pharmaceutical Technology, University Institute of Chemical Technology, North Maharashtra University, Jalgaon 245001, India
    • Dates

       
  • Bulletin of Materials Science | News

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