The aim of the present investigation was to study the role of Al$_2$O$_3$ in the Li$_2$O–CaO–P$_2$O$_5$–SiO$_2$ bioactive glass for improving the bioactivity and other physico-mechanical properties of glass. A comparative studyon structural and physico-mechanical properties and bioactivity of glasses were reported. The structural properties of glasses were investigated by X-ray diffraction, Fourier transform infrared spectrometry, scanning electronmicroscopy and the bioactivity of the glasses was evaluated by in vitro test in simulated body fluid (SBF). Density, compressive strength, Vickers hardness and ultrasonic wave velocity of glass samples were measured to investigatephysical and mechanical properties. Results indicated that partial molar replacement of Li$_2$O by Al$_2$O$_3$ resulted in a significant increase in mechanical properties of glasses. In vitro studies of samples in SBF had shown that the pH of the solution increased after immersion of samples during the initial stage and then after reaching maxima it decreased with the increase in the immersion time. In vitro test in SBF indicated that the addition of Al$_2$O$_3$ up to 1.5 mol% resulted in an increase in bioactivity where as further addition of Al$_2$O$_3$ caused a decrease in bioactivity of the samples. The biocompatibility of these bioactive glass samples was studied using human osteoblast (MG-63) cell lines. The results obtained suggested that Li$_2$O–CaO–Al$_2$O$_3$–P$_2$O$_5$–SiO$_2$-based bioactive glasses containing alumina would be potential materials for biomedical applications.
Volume 43, 2020
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