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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/037/03/0729-0733

    • Keywords

       

      Biomineralization; chitosan; simulated body fluid; bioactivity; biocomposite.

    • Abstract

       

      A resorbable composite which acts as a active barrier in guided bone regeneration was fabricated using chitosan, demineralized bone matrix and bone ash. Its potential to form bone like apatite in simulated body fluid was assessed in this study. The mechanical strength of these composites was correlated with bone ash ratios and composites with better tensile strength were studied for their acellular bioactivity by incubating in simulated body fluid for 21 days. Composites without bone ash did not show acellular bioactivity which was confirmed by thermogravimetric analysis. In case of biocomposites with bone ash, there was an increase in residual weight indicating the mineralization of the composite. The composite containing bone ash has shown the peaks related to phosphate vibrations in its Fourier-transform infrared spectrum. Scanning micrographs revealed formation of apatite like crystals on its surface. Ca/P ratio was found to be 1.7 which is nearer to that of natural bone. Thus, prepared composites can be used as resorbable biocomposite in maxillofacial and oral defects.

    • Author Affiliations

       

      Krithiga Gunasekaran1 Santhosh Kumar Baskar1 Divya Sapphire Mohan1 Thotapalli P Sastry1

      1. Bio-Products Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India
    • Dates

       

© 2017-2019 Indian Academy of Sciences, Bengaluru.