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      https://www.ias.ac.in/article/fulltext/boms/036/07/1165-1170

    • Keywords

       

      Collagen; iron nanoparticle; nanohydroxyapatite; MTT assay; wet precipitation method.

    • Abstract

       

      A simple wet precipitation technique was used to prepare nanobiocomposite containing iron nanoparticles coated with collagen. This nanobiocomposite was used as matrix for the synthesis of nanohydroxyapatite. The physicochemical characteristic studies of the nanohydroxyapatite thus formed were carried out using fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, energydispersive X-ray spectroscopy and X-ray diffraction technique to confirm the formation of hydroxyapatite on iron nanoparticle–collagen complex. The results of the above studies supported the formation of iron nanoparticle–collagen–hydroxyapatite composite. The biological studies such as biocompatibility and hemocompatibility were carried out for nanohydroxyapatite using different cell lines and blood sample. The results of biocompatibility and hemolytic assay revealed that the prepared nanobiocomposite was 100 % biocompatible and hemocompatible. This nanobiocomposite may be used for biomedical application such as injectables for targeted delivery and as scaffold for tissue engineering.

    • Author Affiliations

       

      M Chamundeeswari1 B Santhosh Kumar2 T Muthukumar2 L Muthuraman1 K Purna Sai3 T P Sastry2

      1. St. Joseph’s College of Engineering, Sholinganallur, Chennai 600 119, India
      2. Bio-Products Lab, Central Leather Research Institute, Chennai 600 020, India
      3. Biomaterials Division, Central Leather Research Institute, Chennai 600 113, India
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    • Supplementary Material

       
  • Bulletin of Materials Science | News

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