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    • Biodegradable poly(lactic acid) microspheres containing total alkaloids of Caulis sinomenii

      Wen Zhang Xiaojie Lin Xingxiang Zhang

      Volume 34 Issue 7 December 2011 pp 1715-1719

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/034/07/1715-1719

    • Keywords

       

      Microsphere; Caulis sinomenii; PLA; drug release; rheumatoid arthritis.

    • Abstract

       

      The fabrication of biodegradable poly(lactic acid) (PLA) microspheres containing total alkaloids of Caulis sinomenii was investigated. The formation, diameter, morphology and properties of the microspheres were characterized using Fourier transform infrared spectroscopy (FT–IR), laser particle size analyser and scanning electron microscopy (SEM), etc. In vitro releasing behaviour was also investigated using UV-Vis spectrometer. As a result, the drug-loaded microspheres with a narrower distributive, rounder and smoother surface were prepared. Drug-releasing behaviour from microspheres was affected by the concentration of emulsifier and the stirring rate. The results demonstrated that a medicated system, which can be potentially applied within a drug delivery system, was designed. This system acts in a systematic manner for the treatment of rheumatoid arthritis.

    • Author Affiliations

       

      Wen Zhang1 Xiaojie Lin1 Xingxiang Zhang1

      1. Institute of Functional Fibers, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300160, China

    • Dates

       
      Published
      December 2011
      Manuscript received
      21 May 2010
      Manuscript revised
      23 August 2010

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