• Spectroscopic, thermal and biological studies of coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes

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    • Keywords


      Infrared spectra; electronic spectra; thermal analysis; sulfasalazine; antimicrobial activity.

    • Abstract


      The complexations of sulfasalazine (H3Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)-2(H2O)4].2H2O, [M(HSuz)-2(H2O)2].𝑥H2O (M = Hg(II), ZrO(II) and VO(II), 𝑥 = 4, 8 and 6, respectively) and [M(HSuz)-2(Cl)(H2O)3].𝑥H2O (M = Cr(III) and Y(III), 𝑥 = 5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the sulfasalazine behaves as a monoanionic bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (𝛥 𝐸*}, 𝛥 𝐻*, 𝛥 𝑆* and 𝛥 𝐺*) were estimated using Coats–Redfern and Horowitz–Metzger equations. In vitro antimicrobial activities of the H3Suz and the complexes were tested.

    • Author Affiliations


      M G Abd El-Wahed1 M S Refat2 S M El-Megharbel1

      1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
      2. Department of Chemistry, Faculty of Science, Port Said, Suez Canal University, Port Said, Egypt
    • Dates

  • Bulletin of Materials Science | News

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