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    • Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid

      K Kumari P P Kundu

      Polymers Volume 31 Issue 2 April 2008 pp 159-167

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/031/02/0159-0167

    • Keywords

       

      Beads; chitosan; IPNs; release; swelling.

    • Abstract

       

      Interpenetrating polymer network (IPN) beads consisting of chitosan–glutamic acid were prepared for in vitro study of controlled release of chlorpheniramine maleate (CPM). A viscous solution of chitosan–glutamic acid was prepared in 2% acetic acid solution, extruded as droplets through a syringe to alkali–methanol solution and the precipitated beads were crosslinked using glutaraldehyde solution. Swelling and drug release studies were carried out. Transport of release medium through the semi-IPN depended upon its pH and extent of crosslinking. The structural and morphological studies of beads were carried out by using a scanning electron microscope (SEM). The larger surface area of beads as well as their ease of handling makes them ideal agents of controlled release.

    • Author Affiliations

       

      K Kumari1 P P Kundu1

      1. Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148 106, India

    • Dates

       
      Published
      April 2008
      Manuscript received
      2 October 2007
      Manuscript revised
      26 October 2007

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