1. Home
    2. Journals
    3. Bulletin of Materials Science
    4. Volume 31
    5. Issue 2

    • Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid

      K Kumari P P Kundu

      Polymers Volume 31 Issue 2 April 2008 pp 159-167

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/boms/031/02/0159-0167

    • Keywords

       

      Beads; chitosan; IPNs; release; swelling.

    • Abstract

       

      Interpenetrating polymer network (IPN) beads consisting of chitosan–glutamic acid were prepared for in vitro study of controlled release of chlorpheniramine maleate (CPM). A viscous solution of chitosan–glutamic acid was prepared in 2% acetic acid solution, extruded as droplets through a syringe to alkali–methanol solution and the precipitated beads were crosslinked using glutaraldehyde solution. Swelling and drug release studies were carried out. Transport of release medium through the semi-IPN depended upon its pH and extent of crosslinking. The structural and morphological studies of beads were carried out by using a scanning electron microscope (SEM). The larger surface area of beads as well as their ease of handling makes them ideal agents of controlled release.

    • Author Affiliations

       

      K Kumari1 P P Kundu1

      1. Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148 106, India

    • Dates

       
      Published
      April 2008
      Manuscript received
      2 October 2007
      Manuscript revised
      26 October 2007

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.

Contact | Site index