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    • Keywords


      Magnetic nanoparticle; surface functionalization; in vivo biodistribution; magnetic resonance imaging (MRI); magnetic hyperthermia; contrast agent.

    • Abstract


      Magnetic nanoparticles have attracted wide attention because of their usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This paper examines these in vivo applications through an understanding of the problems involved and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint, the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells. Then, our synthesis strategies are presented and focused on covalent platforms based on maghemite and dextran and capable to be tailorderivatized by surface molecular chemistry. The opportunity of taking advantage of temperature-dependence of magnetic properties of some complex oxides for controlling the in vivo temperature is also discussed.

    • Author Affiliations


      E Duguet1 S Vasseur1 S Mornet1 G Goglio1 A Demourgues1 J Portier1 F Grasset2 P Veverka3 E Pollert3

      1. Institut de Chimie de la Matière Condensée de Bordeaux, UPR CNRS 9048, Université Bordeaux-1, 87 ave du Dr Albert Schweitzer, 33608 Pessac Cedex, France
      2. Verres et Céramiques, UMR CNRS 6512, Université de Rennes-1, Institut de Chimie de Rennes, CS 74 205, 35042 Rennes Cedex, France
      3. Institute of Physics, ASCR, 162 53 Praha 6, Czech Republic
    • Dates

  • Bulletin of Materials Science | News

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