• On the relevance and requirements of biomaterials

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    • Abstract

       

      The technological orientation of current medical practice is reflected in the effective utilization of a number of diagnostic and therapeutic devices. Synthetic and natural biomaterials alone or in combination form the basis for development of such devices that are in contact with different tissues. The effect of materials on tissues andvice versa needs to be understood to ensure safety and effectiveness of the devices. This calls for biological evaluation of materials and devices, in addition to a spectrum of recommended toxicological testing of materials depending upon the duration and the type of tissue in contact with. Besides being non-toxic, the material is required to meet the functional requirements with the appropriate host response which is termed as biocompatibility.

      This paper reviews the evolution and the requirements of biomaterials. Thein vitro andin vivo evolution methodologies are highlighted based on our experience in developing blood bag, dental composite, hydroxyapatite and fibrin glue. The requirements of biomaterials in the current context of advances in the fields of tissue engineering and biomimetics is outlined.

    • Author Affiliations

       

      R Sivakumar1

      1. Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum - 695 012, India
    • Dates

       
  • Bulletin of Materials Science | News

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