• Effect of imipramine and amitriptyline on circadian locomotor activity rhythm in the field mouseMus booduga

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      https://www.ias.ac.in/article/fulltext/anml/099/06/0503-0507

    • Keywords

       

      Mus booduga ; period lengthening; imipramine; amitriptyline; amount of activity

    • Abstract

       

      We have performed experiments on the influence of imipramine and amitriptyline (antidepressant drugs) offered through drinking water on the period length (τ) of the circadian locomotor activity rhythm in the field mouseMus booduga under continuous darkness (DD). Ingestion of imipramine to mice under freemnning conditions caused lengthening of the activity rhythm whereas amitriptyline caused dissociation of activity components. Furthermore, the amount of activity (α) is significantly reduced (P< 0-005) during imipramine as well as amitriptyline treatment. The action of these antidepressants may be explained by their action on serotonergic terminals in the suprachiasmatic nucleus, the putative circadian pacemaker in mammals.

    • Author Affiliations

       

      P Subramanian1 R Subbaraj1

      1. Department of Animal Behaviour, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625 021, India
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