• In vivo effect of dimethoate on acetylcholinesterases from a freshwater teleost,Notopterus notopterus

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/anml/099/01/0053-0056

    • Keywords

       

      Dimethoate; acetylcholinesterases; Notopterus

    • Abstract

       

      The effect of exposure to dimethoate, an organophosphorus insecticide, on the activity of soluble and membrane-bound fractions of acetylecholinesterases from the brain of the Indian razor-fish,Notopterus notopterus was studied. The fishes were exposed to a concentration of 2 ppm of the insecticide for a period of 4 weeks. The two fractions of the enzyme exhibited a reduced efficiency, as indicated byVmax/Km ratios. The exposure to the insecticide resulted in 96·25% reduction in VmJKm for the membrane-bound fraction and 68·7% reduction in the corresponding value for the soluble enzyme as compared to those of the control set of fishes.

    • Author Affiliations

       

      R S Hande1 P V Pradhan1

      1. Department of Biological Sciences, R J College, Ghatkopar, Bombay - 400 086, India
    • Dates

       
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