BHISMA K PATEL

Indian Institute of Technology Guwahati

Bhisma Kumar Patel is presently Professor and Head – Department of Chemistry at the Indian Institute of Technology Guwahati. He holds a PhD in Chemistry from IIT Kanpur and a Postdoc from the Max-Planck Institute for Experimental Medicine, Germany. His area of research includes study of organic reaction mechanisms, synthesis of heterocycles, biosensors, green chemistry, metal catalysed oxidative functionalization, C-H bond activation (metal and metal free), and hypervalent iodine mediated organic transformations. He is the recipient of many prestigious awards including the Costal Chemical Research Society Award – 2016 and CRSI Bronze Medal – 2014. He has served as the Dean of Student’s Affairs, Chairman GATE, Chairman DRDO SET and as a member of the Board of Governors at IIT Guwahati and NIT Nagaland. He is a Fellow of the National Academy of Sciences, India, and has been elected as a Fellow of the Indian Academy of Sciences in 2018.

BHISMA K PATEL

SESSION 2D: Inaugural lectures by Fellows/Associates

R K Srivastava, BHU, Varanasi

Fluorescent, AIEgen and cytotoxic behaviour of annulated polycyclic heteroaromatics

Polycyclic aromatic hydrocarbons (PAHs) constitute an important class of molecules in material science due to their applications in electronic devices, semiconductors, solar cells, fluorescent probes and cancer cell imaging. Incorporation of heteroatoms (N, O or S) into PAHs can fine tune their chemical, physical and supramolecular properties. Transition-metal catalyzed aromatic C−H activation of arenes, hetero-arenes and alkynes has been a powerful synthetic strategy to access various polycylic heteroaromatics. The speaker will discuss Ruthenium(II) catalyzed oxidative C−H / O−H and C−H / S−H annulations that have been demonstrated by his team using different directing arenes, viz., 2-arylquinolinone, 2-arylbenzoxazinone, quinoline-4(1H)-thiones and quinoxaline with internal alkynes. He will also talk about Regiospecific annulations that have been observed for directing arenes via the assistance of weaker carbonyl or thio carbonyl groups in the presence of a stronger nitrogen-directing site. Some of the synthesized polycyclic hetero-aromatics are water soluble exhibiting fluorescence and aggregation induced emission (AIE). These AIE luminogens are highly cytotoxic against HeLa cell line and some have found application as fluorescent ‘light-up’ probes for cell imaging.

© 2018 Indian Academy of Sciences, Bengaluru.