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The author received his PhD in physics from the University of
Chicago. His research interests lie in the areas of developmental
biology and evolution.
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On February 28, 1953, in a pub in Cambridge, Francis
Crick was telling everyone who cared to listen that he and James Watson
had just discovered the secret of life. The April 25 issue of the
journal Nature carried the same news in the form of their first, and
most famous, paper, “A Structure for Deoxyribose Nucleic Acid”.
In it they announced that DNA, the molecular basis of heredity, was a
right-handed double helix. It consisted of two intertwined,
anti-parallel helical strands. Each strand was a long molecule
made up of subunits which contained a sugar, deoxyribose, a
phosphate group, and one of the four bases adenine (A), guanine (G),
thymine (T) and cytosine (C). The two strands specified each
other; they were ‘complementary’. This was because they were held
together by hydrogen bonds formed between adenine and thymine (A-T) and
between guanine and cytosine (G-C). On May 30 there was a
follow-up by Watson and Crick in the same journal, entitled “Genetical
Implications of the Structure of Deoxyribonucleic Acid”. It was
seen by Luis Alvarez and brought by him to the attention of George
Gamow, then visiting the University of California at Berkeley.
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Address for Correspondence
Vidyanand Nanjundiah
Indian Institute of Science and Jawaharlal Nehru Centre for Advanced
Scientific Research
Bangalore 560 012, India.
Email: vidya@ces.iisc.ernet.in
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