PowerPoint Presentation
Slide 2
Receptor-mediated endocytosis
Slide 4
Publications – Direct therapeutic approaches
Importance of ECM recognition
Publications – ECM interactions
Slide 8
L. donovani, when attached to the macrophage surface, behaves like any other microbe which are killed by macrophages, but once internalized it somehow switches off the activation signaling for downstream oxidative events.
Slide 10
Nitric Oxide Synthase (NOS) activity in L. donovani
Slide 12
Guanylate cyclase (GC) activity
Effect of various effectors on GC activity
Inhibitory effect of Ca2+ and calmodulin modulators on GC activity and L. donovani infectivity
Role of intracellular Ca2+ content on GC activity and infectivity
Slide 17
Cloning of guanylate cyclase gene
Slide 19
Slide 20
Slide 21
Slide 22
Slide 23
Functional analysis of recombinant protein
Immunolocalization
Summary
Slide 27
Slide 28
Author: OpenOffice.org-1.1