pp 673-673 Editorial
pp 676-676 Science Smiles
pp 677-694 General Article
James N Gray (Jim Gray) was a computer scientist whosemajor contributions include formalising a theory for reliabletransaction processing of large databases and implementingsystems based on his theory. This work was crucial to implementreliable financial transactions by banks and other financialinstitutions. (Financial transactions are a subset of alltransactions.) In addition, he is credited with coining the termFourth Paradigm, i.e., data driven scientific discovery byscientists who collect humongous amount of data with modernscientific instruments. He also collaborated with diversegroups of scientists to organize the data collected by them tofacilitate easy retrieval and interpretation.
pp 695-716 General Article
The volume and variety of data being generated using computersis doubling every two years. It is estimated that in 2015,8 Zettabytes (Zetta=1021) were generated which consistedmostly of unstructured data such as emails, blogs, Twitter,Facebook posts, images, and videos. This is called big data. Itis possible to analyse such huge data collections with clustersof thousands of inexpensive computers to discover patterns inthe data that have many applications. But analysing massiveamounts of data available in the Internet has the potential ofimpinging on our privacy. Inappropriate analysis of big datacan lead to misleading conclusions. In this article, we explainwhat is big data, how it is analysed, and give some case studiesillustrating the potentials and pitfalls of big data analytics.
pp 717-740 General Article
In this part we shall outline the challenges one faces whiledeveloping time-domain radiofrequency (RF) EPR imagingspectrometer for in vivo studies. Time-domain or FT-EPR isquite a different animal compared to the CW modality. Theevolution of FT-EPR instrumentation at the National CancerInstitute, NIH, USA and representative examples of applicationin cancer research are outlined in this article.
pp 741-747 General Article
G N Ramachandran made several remarkable contributionsto biophysics and structural biologyover the course of his celebrated career. In a pairof seminal papers in 1971, he also laid the foundationfor the technique of ‘Projection Reconstruction’that has come to revolutionize medicalimaging. It is now routinely employed in modernCT (Computed Tomography) and MRI (MagneticResonance Imaging) scans. In this article,we review the salient features of this technique,that allows the ‘reconstruction of an object fromits shadows’.
pp 749-763 Classics
pp 765-765 Information and Announcements
pp 766-766 Information and Announcements
pp 767-767 Flowering Trees