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      http://www.ias.ac.in/article/fulltext/jbsc/027/01/0067-0070

    • Keywords

       

      Angiotensin-converting enzyme; ethnicity; Indians; polymorphism

    • Abstract

       

      The pattern of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in the Indian population is poorly known. In order to determine the status of the polymorphism, young unrelated male army recruits were screened. The population had cultural and linguistic differences and lived in an environment that varied significantly from one region to another. Analysis of the genotype, showed higher frequency of the insertion allele in four of the five groups i.e. I allele frequency was significantly higher (𝑃 < 0.05) in Dogras, Assamese and Kumaonese. The deletion allele frequency was comparatively higher in the fifth group that belonged to Punjab. A correlation was observed between the genotype and enzyme activity. Involvement of a single D allele in the genotype enhanced the activity up to 37.56 ± 3.13%. The results suggested ethnic heterogeneity with a significant gene cline with higher insertion allele frequency. Such population-based data on various polymorphisms can ultimately be exploited in pharmacogenomics.

    • Author Affiliations

       

      M A Qadar Pasha1 Amjad P Khan1 Ratan Kumar2 Rekh B Ram1 Surinder K Grover2 Kaushal K Srivastava2 William Selvamurthy2 Samir K Brahmachari1

      1. Functional Genomics Unit, Centre for Biochemical Technology, Mall Road, Delhi 110 007, India
      2. Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110 054, India
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