Synthesis
of New dihydropyrimidinones catalysed by dicationic ionic
liquid
DHANAJI V JAWALE,
UMESH R PRATAP, APARNA A MULAY, JYOTIRLING R MALI
and RAMRAO A MANE*
Department of
Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004,
India
e-mail:
manera2011@gmail.com
MS received 21
December 2010; accepted 17 May 2011
Abstract.
A convenient multi step synthetic protocol for new
dihydropyrimidinones bearing quinolynyl
methoxy phenyl
moiety has been developed from 2-chloro-3-formyl quinolines. The last step is
one-pot Biginelli
reaction of
multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl
acetoacetate and
urea mediated and
catalysed by dicationic ionic liquid
(3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]-
1H-imidazolium
dibromide (C3 [min]2 2 [Br−] )). Simple work-up procedures and moderate to good yields of
the pyrimidinones
and the intermediates are the merits of the route.
Graphical
Abstract. A
convenient multistep synthetic protocol for new dihydropyrimidinones
bearing quinolynyl methoxy phenyl
moiety has been developed from 2-chloro-
3-formyl quinolines.
Keywords. Dihydropyrimidinones; quinoline; dicationic ionic liquid;
ethereal linkage; Biginelli reaction.