Synthesis of New dihydropyrimidinones catalysed by dicationic ionic
DHANAJI V JAWALE, UMESH R PRATAP, APARNA A MULAY, JYOTIRLING R MALI
and RAMRAO A MANE*
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India
MS received 21 December 2010; accepted 17 May 2011
Abstract. A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl
methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli
reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and
urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]-
1H-imidazolium dibromide (C3 [min]2 2 [Br−] )). Simple work-up procedures and moderate to good yields of
the pyrimidinones and the intermediates are the merits of the route.
Graphical Abstract. A convenient multistep synthetic protocol for new dihydropyrimidinones
bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-
Keywords. Dihydropyrimidinones; quinoline; dicationic ionic liquid; ethereal linkage; Biginelli reaction.