Trifluoromethanesulfonic acid promoted Dakin–West reaction: An
efficient and convenient synthesis of β-acetamido ketones
RAVINDRA M KUMBHARE* and MADABHUSHI SRIDHAR
Fluoroorganics Division, Indian Institute of Chemical Technology, Hyderabad 500607, India
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Abstract. Trifluoromethanesulfonic acid promoted efficient condensation of an aromatic aldehyde with an
acetophenone and acetonitrile in the presence of acetylchloride as an activator producing β-acetamido carbonyl
compounds is described.
Graphical Abstract. b-Acetamido carbonyls were synthesized by triflic acid promoted Dakin-West
reaction of aryl aldehydes, aryl ketones and acetonitrile.
Keywords. β-Acetamido ketones; Dakin–West reaction; multicomponent synthesis;