Trifluoromethanesulfonic acid promoted Dakin–West reaction: An

efficient and convenient synthesis of β-acetamido ketones

RAVINDRA M KUMBHARE* and MADABHUSHI SRIDHAR

Fluoroorganics Division, Indian Institute of Chemical Technology, Hyderabad 500607, India

e-mail: rakumbhare@yahoo.com, kumbhare@iict.res.in

Abstract. Trifluoromethanesulfonic acid promoted efficient condensation of an aromatic aldehyde with an

acetophenone and acetonitrile in the presence of acetylchloride as an activator producing β-acetamido carbonyl

compounds is described.

Graphical Abstract. b-Acetamido carbonyls were synthesized by triflic acid promoted Dakin-West

reaction of aryl aldehydes, aryl ketones and acetonitrile.

Keywords. β-Acetamido ketones; Dakin–West reaction; multicomponent synthesis;

trifluoromethanesulfonic acid.